{"id":3997,"date":"2020-05-19T20:08:00","date_gmt":"2020-05-19T18:08:00","guid":{"rendered":"https:\/\/re-mic.de\/?p=3997"},"modified":"2020-05-19T12:13:10","modified_gmt":"2020-05-19T10:13:10","slug":"consistency-of-parametric-registration-in-serial-mri-studies-of-brain-tumor-progression","status":"publish","type":"post","link":"https:\/\/re-mic.de\/en\/2020\/05\/consistency-of-parametric-registration-in-serial-mri-studies-of-brain-tumor-progression\/","title":{"rendered":"Consistency of parametric registration in serial MRI studies of brain tumor progression"},"content":{"rendered":"<p><em>Andreas Mang, Julia A. Schnabel, William R. Crum, Marc Modat, Oscar Camara-Rey, Christoph Palm, Gisele Brasil Caseiras, H. Rolf J\u00e4ger, S\u00e9bastien Ourselin, Thorsten M. Buzug, David J. Hawkes<\/em><\/p>\n<p>Object&#13;<br \/>\nThe consistency of parametric registration in multi-temporal magnetic resonance (MR) imaging studies was evaluated.&#13;<br \/>\nMaterials and methods&#13;<br \/>\nSerial MRI scans of adult patients with a brain tumor (glioma) were aligned by parametric registration. The performance of low-order spatial alignment (6\/9\/12 degrees of freedom) of different 3D serial MR-weighted images is evaluated. A registration protocol for the alignment of all images to one reference coordinate system at baseline is presented. Registration results were evaluated for both, multimodal intra-timepoint and mono-modal multi-temporal registration. The latter case might present a challenge to automatic intensity-based registration algorithms due to ill-defined correspondences. The performance of our algorithm was assessed by testing the inverse registration consistency. Four different similarity measures were evaluated to assess consistency.&#13;<br \/>\nResults&#13;<br \/>\nCareful visual inspection suggests that images are well aligned, but their consistency may be imperfect. Sub-voxel inconsistency within the brain was found for allsimilarity measures used for parametric multi-temporal registration. T1-weighted images were most reliable for establishing spatial correspondence between different timepoints.&#13;<br \/>\nConclusions&#13;<br \/>\nThe parametric registration algorithm is feasible for use in this application. The sub-voxel resolution mean displacement error of registration transformations demonstrates that the algorithm converges to an almost identical solution for forward and reverse registration.<\/p>\n<div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-blog so-widget-sow-blog-grid-c34ffc02d075\"\n\t\t\t\n\t\t>\t\t<div\n\t\tclass=\"sow-blog 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status-publish hentry\" style=\"margin: 0 0 30px;\">\n\t\t\t\t<div class=\"sow-blog-content-wrapper\"\n\t\t style=\"padding: 20px 25px;\">\n\t\t\t\t<header class=\"sow-entry-header\">\n\t\t\t<h4 class=\"sow-entry-title\" style=\"margin: 0 0 5px;\"><a href=\"https:\/\/re-mic.de\/en\/privacy-policy\/\" rel=\"bookmark\">Privacy policy<\/a><\/h4>\t\t\t<div class=\"sow-entry-meta\">\n\t\t\t\t\n\t\t\n\t\t\n\t\t\t\t\t<\/div>\n\t\t<\/header>\n\n\t\t\t<\/div>\n<\/article>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Andreas Mang, Julia A. Schnabel, William R. Crum, Marc Modat, Oscar Camara-Rey, Christoph Palm, Gisele Brasil Caseiras, H. Rolf J\u00e4ger, S\u00e9bastien Ourselin, Thorsten M. Buzug, David J. Hawkes Object&#13; The consistency of parametric registration in multi-temporal magnetic resonance (MR) imaging studies was evaluated.&#13; Materials and methods&#13; Serial MRI scans of adult patients with a brain&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-3997","post","type-post","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"https:\/\/re-mic.de\/en\/wp-json\/wp\/v2\/posts\/3997","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/re-mic.de\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/re-mic.de\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/re-mic.de\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/re-mic.de\/en\/wp-json\/wp\/v2\/comments?post=3997"}],"version-history":[{"count":1,"href":"https:\/\/re-mic.de\/en\/wp-json\/wp\/v2\/posts\/3997\/revisions"}],"predecessor-version":[{"id":4084,"href":"https:\/\/re-mic.de\/en\/wp-json\/wp\/v2\/posts\/3997\/revisions\/4084"}],"wp:attachment":[{"href":"https:\/\/re-mic.de\/en\/wp-json\/wp\/v2\/media?parent=3997"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/re-mic.de\/en\/wp-json\/wp\/v2\/categories?post=3997"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/re-mic.de\/en\/wp-json\/wp\/v2\/tags?post=3997"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}